Normal Bone Turnover in Transient Hyperphosphatasemia

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Normal Bone Turnover in Transient Hyperphosphatasemia

Transient hyperphosphatasemia of infancy and early childhood (THI) is characterized by a temporary isolated elevation of serum alkaline phosphatase activity (ALP), predominantly its bone or liver isoform, in either sick or healthy children under 5 years of age. Return to normal ALP levels usually occurs within four months. Spontaneous rise of ALP might concern the physician, especially when tre...

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Transient hyperphosphatasemia in children.

Transient Hyperphosphatasemia (TH) is a benign condition in which serum alkaline phosphatase (ALP) is transiently elevated in the absence of other systemic diseases. It mainly occurs in infants and children and very rarely seen in adults. The differential diagnosis may include liver, bone, kidney, intestinal, placental and blood diseases as well as other serious conditions as well as bone fract...

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bENIgN trANSIENt hyPErPhoSPhAtASEmIA of ChIlDhooD

Objective: To report a case series of benign transient hyperphosphatasemia of infancy (BTHI). Description (Case report): A series of four girls with BTHI is described. The age range was 11-45 months (median: 13 months). At diagnosis, the serum alkaline phosphatase was 1.16.1 times (median: 1.36) above the reference values. Return to normal values occurred between 7-11 months (median: 9 months)....

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Recurrent transient hyperphosphatasemia of infancy in an adult.

We report a case of recurrent transient hyperphosphatasemia in a 29-year-old man with immune deficiency. He had serum alkaline phosphatase (ALP; EC 3.1.3.1) activity 16.9- and 4.8-fold greater than the upper reference limit on two occasions; the activity returned to normal within 2 months on the first and within 1 month on the second. On both occasions we observed the typical electrophoretic pa...

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Transient hyperphosphatasemia of infancy--an insufficiently recognized syndrome.

Spectacular transient increases in serum alkaline phosphatase were observed in five infants in the absence of demonstrable pathology.

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ژورنال

عنوان ژورنال: Journal of Clinical Research in Pediatric Endocrinology

سال: 2012

ISSN: 1308-5727

DOI: 10.4274/jcrpe.680